Pilot freeze-dryer
Comfort freeze drying with isolator
Product description
The innovative integrated system Epsilon 2-10D LyoLift ensures reliable and convenient freeze drying for applications where safety is a major factor. It consists of three mutually compatible components: the freeze dryer, the loading system and the isolator.
The high-performance pilot freeze dryer Epsilon 2-10D LSCplus is designed to meet the highest demands of the pharmaceutical and biotech industries. The personal protection isolator provides good protection by creating a barrier between the operator and product (isolator enclosure with gloves).
The innovative LyoLift makes loading and unloading the freeze dryer in the isolator remarkably convenient. The semi-automatic system allows the loading table to be raised and lowered using a foot switch on the shelves, without endangering the product.
Other LyoLift features:
- All motions are guided and supported
- Hygienic design for easy cleaning (suitable for WIP)
- Mechanical and electrical protection devices ensure safe loading and unloading
- Flexible interfaces to filling systems
Technical data
| Ice condenser capacity: | 10 kg |
| Ice condenser temperature: | –88 °C |
| Shelf dimensions: | 350 × 400 mm (W × D) |
| Number of shelves: | 4 |
| Shelf area: | 0,56 m² |
| Shelf temperature: | –55 °C to +60 °C |
| Shelf temperature accuracy: | max. ±1 °C |
| Cooling systems: | 2 independent systems, air cooled (optionally water chilled) |
| Ice condenser cooling system: | 2 compressors, 1.2 kW each, in cascade configuration |
| Shelf cooling system: | 1 compressor, 0.9 kW |
| Unit dimensions: | 2500 × 2236 × 1739 mm (H × W × D) |
| 10R Vials: | 1016 |
WTMplus 2.0 – Wireless Temperature Measurement
The WTMplus 2.0 (wireless product temperature measurement system) avoids the disadvantages arising from the use of wired temperature sensors. It is significantly easier to use in practice. There is no need for temperature sensor cables or connectors inside the vacuum chamber. The wireless self-powered sensors are placed manually or automatically when the product vials or dishes are filled and report the corresponding product temperatures to the unit controller during the entire lyophilisation process.
Technical data
| Probe dimensions | Length: 21 mm plus 29 mm flexible antenna Diameter: 2.8 mm |
| Temperature measuring range | –60 °C to +135 °C |
| Measurement accuracy | ±1,0 K |
| Temperature resolution | 0.1 K |
Comparative pressure measurement
In addition to product temperature measurement and pressure rise testing, the simultaneous use of two vacuum sensors with different measuring principles can provide information about the progress of the drying process. The commonly used Pirani gauge indicates higher absolute pressures at the start of the primary drying phase because its operation is dependent on the gas type and large amounts of water vapour are released at the start of the primary drying phase. By contrast, capacitive pressure sensors are independent of the gas type. The approaching end of the primary drying phase, which occurs when there is no longer a significant concentration of water vapour, is indicated by the gradual approach of the two pressure curves to each other during the process.
Sample extraction system
The sample extraction system allows individual sample containers to be removed under vacuum during the drying process without interrupting the drying process. This is done by using a gripper arm to pick up the sample container, close it, and remove it through a vacuum lock. This allows individual sample containers or vials to be removed from the freeze dryer at defined intervals. The samples removed through the vacuum lock can be investigated and analysed in parallel with the ongoing process. This allows the progress of the process to be measured and documented in detail.
Technical data
| Sample containers/vials: | 6R to 30R Max. 50H |
| Coupling flange: | DN 160 clamp |
| Gripper working range: | 200 mm |
| Stoppering device: | Teflon-coated plunger |
| Vacuum lock: | DN50 |
| Materials: | Stainless stell 1.4404 and 1.4435, Teflon, Borosilicate glass |
| Visualisation: | Direct or with a digital camera, lighting fixture and monitor |