Industrial-scale freeze drying requires robust processes that are initially developed on pilot systems and then scaled up. The objective is to develop drying recipes (profiles of vacuum and shelf temperature versus time) that allow the best possible quality to be achieved in the shortest possible time.
Pilot systems must therefore have the same technology and geometry as the subsequent production freeze dryer, such as rectangular product chambers and shelves chilled or heated by liquid media.
Development tools for time-saving optimisation include:
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